Abatacept Treatment Does Not Preserve Renal Function in the Streptozocin-Induced Model of Diabetic Nephropathy
نویسندگان
چکیده
منابع مشابه
Abatacept Treatment Does Not Preserve Renal Function in the Streptozocin-Induced Model of Diabetic Nephropathy
Diabetic nephropathy (DN) is one of the most severe complications of diabetes and remains the largest cause of end-stage renal disease in the Western world. Treatment options are limited and novel therapies that effectively slow disease progression are warranted. Previous work suggested that treatment with CTLA4-Ig (abatacept), a molecule that binds and blocks B7-1 and is licensed for the treat...
متن کاملProtective effect of ginger against the pentylenetetrazole-induced seizure threshold model in streptozocin treated-diabetic mice
Introduction: There is evidence that diabetes affects seizure susceptibility. Ginger (Zingiber officinale Roscoe) which is used in traditional medicine has antioxidant activity and neuroprotective effects. The aim of this study was to evaluate the seizure threshold induced by pentylenetetrazole (PTZ) in diabetic mice after induction of diabetes with streptozocin and to examine the possible ...
متن کاملStreptozocin-induced diabetic mouse model of urinary tract infection.
Diabetics have a higher incidence of urinary tract infection (UTI), are infected with a broader range of uropathogens, and more commonly develop serious UTI sequelae than nondiabetics. To better study UTI in the diabetic host, we created and characterized a murine model of diabetic UTI using the pancreatic islet beta-cell toxin streptozocin in C3H/HeN, C3H/HeJ, and C57BL/6 mouse backgrounds. In...
متن کاملAnti-Diabetic Effects of Amygdalus Lycioides Spach in Streptozocin-Induced Diabetic Rats
Diabetes mellitus is a group of metabolic disorders characterized by elevated blood sugarand abnormalities in insulin secretion and action. There are many anti-diabetic plants, whichmight supply useful sources for developing new medicines that can be used in treatment ofdiabetes mellitus. The primary objective of the present investigation is to evaluate the antidiabeticproperties of the aerial ...
متن کاملEffect of Citrullus Colocynthis pulp on renal function in streptozotocin-induced diabetic rats
Introduction: Diabetic nephropathy is one of the most serious microvascular complications of diabetes and the main cause of end-stage renal disease. Various herbs have been used to control diabetes complications. This study aimed at investigating the effect of Citrullus colocynthis pulp on diabetes-induced renal damage in male rats. ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: PLOS ONE
سال: 2016
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0152315